'New tailor-made biopolymers produced from lignocellulosic sugars waste for highly demanding fire-resistant applications'

Preparation of novel hybrid gels from polyaspartamides and natural alginate or hyaluronate by click reaction


Novel polyaspartamide derivatives with pendant azide groups were prepared and used to prepare click gels. Two bis-alkyne reagents, bis-propargyl-succinate and bis-propargyl hexane urethane, were synthesized and used as the crosslinkers; these materials contain either labile esters or urethane linkages, respectively. Furthermore, biocompatible hybrid click gels were prepared from azide-modified polyaspartamide and either alkynated alginate or hyaluronic acid. These hybrid gels are a promising alternative to conventional gels in various biomedical applications. The gelation behavior and outstanding swelling and deswelling properties of the gels were characterized as a function of their composition and solution pH. The morphology of the microporous gel scaffolds was observed by SEM. The hydrogel exhibited a low cytotoxicity which was evaluated by MTT assay. In addition, the preliminary hydrolytic degradation behavior of the click gels was also examined in PBS at 37 °C.

» Author: Quang Tri Bui, Young-Sil Jeon, Soong Ho Um, Dong June Chung, Ji-Heung Kim … show all 5 hide

» Reference: Journal of Polymer Research February 2015, 22:27 Date: 04 Feb 2015

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This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration